MENLO PARK, Calif. and SINGAPORE, May 10, 2022 (GLOBE NEWSWIRE) — ASLAN Pharmaceuticals (NASDAQ: ASLN), a clinical-stage, immunology-focused biopharmaceutical company developing innovative treatments to transform the lives of patients, today announced that an abstract highlighting new data and insights related to neuronal itch mechanisms through

eblasakimab’s

targeting of IL-13Rα1 has been accepted for late-breaking poster presentation at the Society for Investigative Dermatology (SID) Annual Meeting, to be held in-person from May 18 to 21, 2022, in Portland, Oregon.

Ferda Cevikbas PhD, Head of Translational Sciences at ASLAN, will present findings from an

ex vivo

study in human dorsal root ganglia neurons which showed a significant inhibitory effect of

eblasakimab

on the IL-4 and IL-13 enhanced sensitization of neuronal itch responses. IL-4 and IL-13 are central to the pathogenesis of atopic dermatitis, exacerbate inflammation and exert neuronal enhancer function to itch. Targeting the IL-13Rα1 blocks IL-4 and IL-13 signaling through the Type 2 receptor and could provide a differentiated approach to disrupt the inflammation and heightened itch experienced by AD patients.

2022 Society for Investigative Dermatology Annual Meeting poster details

Title:


New insights into neuronal itch mechanisms by targeting IL-13R

α

1 with eblasakimab

Presentation date and time:

Poster Session 1, Thursday, May 19, 2022, 4:30 – 6:30PM ET

Presenter:

Dr Ferda Cevikbas, Head Translational Sciences, ASLAN Pharmaceuticals

Location:

Oregon Convention Centre, Exhibit Hall A/A1/B

Abstract number:

LB1039

The poster will be available to view online in the Investor Relations section of ASLAN’s website following presentation:

https://ir.aslanpharma.com/

.

About



eblasakimab




Eblasakimab

is a potential first-in-class monoclonal antibody targeting the IL-13 receptor, with the potential to deliver a differentiated safety and efficacy profile as well as an improved dosing regimen for patients. In September 2021, ASLAN announced positive results from the Phase 1b multiple-ascending-dose study that established proof-of-concept of ASLAN004 and supported its potential as a novel treatment for AD.

About ASLAN Pharmaceuticals


ASLAN Pharmaceuticals (Nasdaq: ASLN) is a clinical-stage, immunology-focused biopharmaceutical company developing innovative treatments to transform the lives of patients. ASLAN is currently evaluating

eblasakimab

, a potential first-in-class antibody targeting the IL-13 receptor, in atopic dermatitis, and

farudodstat

, a potent oral inhibitor of the enzyme, DHODH, in autoimmune disease. ASLAN has a team in Menlo Park, California, and in Singapore. For additional information please visit

www.aslanpharma.com

or follow ASLAN on

LinkedIn

.

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