LA JOLLA, Calif., April 27, 2021 (GLOBE NEWSWIRE) — Equillium, Inc. (Nasdaq: EQ) a clinical-stage biotechnology company developing itolizumab to treat severe autoimmune and inflammatory disorders, today announced that three posters will be presented at VIRTUAL IMMUNOLOGY

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, the 2021 American Association of Immunologists (AAI) Annual Meeting to be held May 10-15, 2021.

The first two posters describe itolizumab’s novel mechanism of action and its effect on the inhibition of the CD6/ALCAM pathway. A third poster describes the validation of an assay to monitor the engagement and modulation of CD6 on T cells as a clinical biomarker of treatment with itolizumab. This assay was developed in collaboration with Precision for Medicine, a specialist clinical contract research organization with deep expertise in the development of clinical biomarkers of the immune system.

Title:

Itolizumab-induced Antigenic Modulation of CD6 Inhibits T Cell Activity


First Author

: Dalena Chu, Senior Research Associate, Equillium, Inc.


Poster Session:

Pathologies and Interventions


Date and Time:

Monday, May 10, 6:30


pm – 8:00 pm ET


Abstract ID Number:

929

Title:

Blockade of the CD6-ALCAM pathway modulates effector T cell function


First Author:

Jeanette Ampudia, Scientist, Equillium, Inc.


Poster Session:

Peripheral Lymphocyte Regulation and Maintenance


Date and Time:

Friday May 14, 2021 6:30 pm – 8:00 pm ET


Abstract ID Number:

836

Title

: An Assay to Monitor the Engagement and Modulation of CD6 on T cells as a Clinical Biomarker of Treatment with Itolizumab


First Author:

Angelina R Bisconte, Director of Translational Biology & Biomarker Development, Precision For Medicine


Poster Session:

Cancer and Inflammation


Date and Time:

Monday, May 10, 6:30


pm – 8:00 pm ET


Abstract ID Number:

976

About Itolizumab


Itolizumab is a clinical-stage, first-in-class anti-CD6 monoclonal antibody that selectively targets the CD6-ALCAM pathway. This pathway plays a central role in modulating the activity and trafficking of T cells that drive a number of immuno-inflammatory diseases. Equillium acquired rights to itolizumab through an exclusive partnership with Biocon Limited.

About Equillium


Equillium is a clinical-stage biotechnology company leveraging deep understanding of immunobiology to develop novel products to treat severe autoimmune and inflammatory disorders with high unmet medical need. Equillium is developing itolizumab for multiple severe immuno-inflammatory diseases, including acute graft-versus-host-disease, lupus/lupus nephritis and uncontrolled asthma.

For more information, visit

www.equilliumbio.com

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Investor Contact


Michael Moore

Vice President, Investor Relations & Corporate Communications

+1-619-302-4431


[email protected]

Media Contacts


Aljanae Reynolds

Wheelhouse Life Science Advisors


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